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Faculty Details

Professor

R. Thirumurugan M Pharm., Ph.D.,

Professor
team
Publication details (last five years)
  • ✔ Chinmayee Panda, Thirumurugan Rathinasabapathy, Brandon Metzger, Sheila Dodson, Dirk Hanson, Jody Griffiths, Slavko Komarnytsky (2024); “Efficacy and tolerability of full spectrum hemp oil in dogs living with pain in common household settings”, Front Vet Sci., 11:1384168. doi: 10.3389/fvets.2024.1384168
  • ✔ Grodsky, L.;Wilson, M.; Rathinasabapathy, T.; Komarnytsky, S (2024); “Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States”, Biomolecules, 14, 395. https://doi.org/10.3390/biom14040395
  • ✔ Araújo ERD, Xavier-Santos JB, da Silva VC, de Lima JBF, Schlamb J, Fernandes-Pedrosa MdF, da Silva Júnior AA, de Araújo Júnior RF, Rathinasabapathy T, Moncada M, Esposito D, Guerra GCB and Zucolotto SM (2023); “Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: A novel potential active ingredient for pharmaceuticals”, Front. Pharmacol. 13:1104705. doi: 10.3389/fphar.2022.1104705.
  • ✔ A. Umamaheswari, M. Vijayalakshmi, N. Tamilselvan, S. Sowntharya, R. Thirumurugan, S. Lakshmana Prabu (2023); “Unravelling the Phytochemical and Pharmacognosy Contour of Traditional Medicinal Plant: Pterocarpus marsupium Roxb”, Qeios ID: 4MFJWG. https://doi.org/10.32388/4MFJWG.
  • ✔ Thirumurugan Rathinasabapathy, Jade Lomax, Kavin Srikanth, Debora Esposito, Colin D. Kay, Slavko Komarnytsky (2022); “Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro”, Immuno, 2 (2), 293-306.
  • ✔ Vong CI, Rathinasabapathy T, Moncada M, Komarnytsky S (2022); “All polyphenols are not created equal: exploring the diversity of phenolic metabolites”. J Agric Food Chem., 70 (7), 2077-2091. https://doi.org/10.1021/acs.jafc.1c07179
  • ✔ Rathinasabapathy T, Sakthivel LP, Komarnytsky S (2022); “Plant-based support of respiratory health during viral outbreaks”. J Agric Food Chem., 70 (7), 2064-2076. https://doi.org/10.1021/acs.jafc.1c06227
  • ✔ Esposito LGA, Overbaugh E, Xiong J, Rathinasabapathy T, Komarnytsky S, da Silva DJH, Esposito D (2021); “Immune responses are differentially regulated by root, stem, leaf, and flower extracts of female and male CBD Hemp (Cannabis sativa L.) plants”. Immuno 1 (4), 369-379. https://doi.org/10.3390/immuno1040025
  • ✔ Komarnytsky S, Rathinasabapathy T, Wagner C, Metzger B, Carlisle C, Panda C, Le Brun-Blashka S, Troup JP, Varadharaj S (2021); “Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils”. Int J Mol Sci., 22, 5479. https://doi.org/10.3390/ijms22115479
  • ✔ Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S (2021); “Rheum rhaponticum root extract improves vasomotor menopausal symptoms and estrogen-regulated targets in ovariectomized rat model”. Int J Mol Sci., 22, 1032. https://doi.org/10.3390/ijms22031032
  • ✔ Xiong J, Chan YS, Rathinasabapathy T, Grace MH, Komarnytsky S, Lila MA (2020); “Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model”. Food Chem., 331, 127279. https://doi.org/10.1016/j.foodchem.2020.127279
  • ✔ Tanveer M, Wagner C, ul Haq MI, Ribeiro NC, Rathinasabapathy T, Butt MS, Shehzad A, Komarnytsky S (2020); “Spicing up gastrointestinal health with dietary essential oils”. Phytochemistry Rev., 19(2), 243-263. https://doi.org/10.1007/s11101-020-09664-x
Total papers published (research article, proceedings, patents, chapter in books and reviews) Paper Publications
  • ❖ Research Articles: 34
  • ❖ Review Articles: 06
  • ❖ Patent (s): 01
  • ❖ Chapters in books: 17
Books:
  • 1. S. Surendhar, S. Meganathan, S. Lakshmana Prabu*, R. Thirumurugan*. Exploring the Medicinal Marvels of a Botanical Wonder: Cassia auriculata. In: Proceedings of the 1st International Conference on Recent Advancements in Materials Science and Technology, Volume I. P. Sakthivel, M. Ramalinga Viswanathan, K. Ravichandran (Eds.). Springer Nature Switzerland AG, Gewerbestrasse 11, 6330 Cham, Switzerland. 2024; pp. 213-226.
  • 2. R. Thirumurugan, A. Umamaheswari, A. Puratchikody, S. Lakshmana Prabu, Dinesh Kumar Chellappan; “Strategies to evaluate the quality of herbal products with special emphasis on toxicity, chemical profiling and pharmacokinetics”, 2024, Publisher: CRC Press Taylor & Francis Group, USA.
  • 3. A. Umamaheswari, S.N. Jegasubramaniam, N. Tamilselvan, R. Thirumurugan, S. Lakshmana Prabu; “Polyphenols as Nutraceuticals of modern life”, In: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases, 2024, Publisher: CRC Press Taylor & Francis Group, USA.
  • 4. R. Gowrish, S. Venkatesh, A. K. Naveena, S. Ashnaa, S. Jeevanandham, R. Thirumurugan; Phytochemical analysis and assessment of therapeutic potential of traditional medicinal plant Acorus calamus L – Medicinal Values of Plants, Volume II, Academic Decipher, Mumbai, 2024, 54, pp. 458-469.
  • 5. S Lakshmana Prabu, R. Thirumurugan. M. Rengaswamy, G. Venkatesan; Remediation approaches for the degradation of textile dye effluents as sustaining Environment. In: Sustainability studies: Environmental and Energy Management. Bentham Science Publishers Pte. Ltd, Singapore, 2022, pp. 74-103.
Participation in conference/ symposia/ training
  • 17
Project details (UG & PG)
  • 1. Harnessing Phytotherapy and Biochemical Synergy: An in vitro study of Bryophyllum pinnatum (Lam) and Succinic acid for Urolithiasis treatment (2024)
  • 2. Designer solvents as a green and efficient media for the extraction of carotenoids from Capsicum annum L. (2023)
  • 3. Designing of Natural Deep Eutectic Solvents as Extractants for the Isolation of Phycocyanin (2023)
  • 4. Adsorption of phytonutrients to foxtail millet flour enables natural fortification of foods (Principal Investigator), IMU BSc Pharmaceutical Chemistry (Hons) Project Grant, December 2015 - April 2016.
  • 5. Synthesis of Hybrid analogues of Zingerone (Principal Investigator), IMU BPharmacy (Hons) Project Grant (BP I-01/12(17)2015), May 2015 - October 2015.
  • 6. Antidiabetic effects of 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine in Streptozotocin-Nicotinamide induced diabetic rats (Co-Researcher), IMU BMedSci Project Grant [BMS I02/2014 (05)], October 2014 - June 2015.
  • 7. Identification of chemical probes with pancreatic β-cell-selective replication promoting activity: The new paradigm in anti-diabetic drug discovery (Co-Researcher), FRGS, Ministry of Higher Education, Govt. of Malaysia (FRGS/1/2014/SG01/IMU/03/1), July 2014 - December 2016.
  • 8. Swietenine, a natural wonder drug, potentiates the antidiabetic activity of metformin: Identification of molecular mechanisms involved (Co-Researcher), FRGS, Ministry of Higher Education, Govt. of Malaysia (FRGS/1/2014/STWN10/IMU/02/1), July 2014 - June 2016.
  • 9. Structure-based Optimisation of the novel lead compound Tetrahydrothiazolopyridine for the treatment of obesity: Design and synthesis of drug-like compounds; evaluation of their efficacy and toxicity in vivo (Principal Investigator), ERGS, Ministry of Higher Education, Govt. of Malaysia (ERGS/1/2013/SKK02/IMU/03/1), June 2013 - December 2016.
  • 10. Synthesis of Oxathiazole Prodrugs of Phenethylisothiocyanate – A novel Prodrug approach to improve its bioavailability in vitro (Principal Investigator), IMU BPharmacy (Hons) Project Grant (BP I-01/11(26)2014), May 2014 - October 2014.
  • 11. Design and synthesis of Tetrahydrothiazolopyridine derivatives as novel and selective 11β-Hydroxysteroid dehydrogenase1 (11β-HSD1) inhibitors (Principal Investigator), IMU Research Seed Grant (IMU 263/2012), December 2012 - December 2013.
  • 12. Artemisia Species and Insulin Signaling (Co-Researcher), BRC-NIH Grant (1-P50 AT0002776-01), 2010 - 2012.
Awards received
  • Honoured with the Academic Excellence Award by Sree Abirami Institutions during the 12th Graduation Day ceremony, presented by Dr. K. Narayanasamy, Vice Chancellor of The Tamil Nadu Dr. M.G.R. Medical University, Chennai.
  • Funds Received
  • RM 190,000
  • Title: Structure-Based Optimization of the Novel Lead Compound Tetrahydrothiazolopyridine for the Treatment of Obesity: Design and Synthesis of Drug-like Compounds; Evaluation of Their Efficacy and Toxicity In Vivo
  • Role: Principal Investigator
  • Funding Agency: Exploratory Research Grant Scheme (ERGS), Ministry of Higher Education, Government of Malaysia
  • Grant Number: ERGS/1/2013/SKK02/IMU/03/1
  • Duration: June 2013 – December 2016
  • RM 20,000
  • Title: Design and synthesis of Tetrahydrothiazolopyridine derivatives as novel and selective 11β-Hydroxysteroid dehydrogenase1 (11β-HSD1) inhibitors.
  • Role: Principal Investigator
  • Funding Agency: IMU Research Seed Grant
  • Grant Number: IMU 263/2012
  • Duration: December 2012 - December 2013.
Abroad Visits
  • Postdoctoral Research Scholar
    Plants for Human Health Institute, College of Agriculture and Life Sciences (CALS), North Carolina State University (NCSU), Kannapolis, NC, USA (November 2016 – October 2022).